The new Parsum IPP-80 in-line particle sizing probe: robust, trouble free granulation monitoring

13 March 2015

The new Parsum IPP-80 probe from Malvern Instruments brings easy to integrate inline particle size measurement for efficient process monitoring and control. Suitable for powders, pellets and granules the new probe enables the real-time monitoring of agglomeration, coating and granulation processes. The resulting data provide a secure basis for pilot plant studies, process optimisation and control. A robust, sanitary design delivers long-running operation with minimal attention and includes in-built self-diagnostic tools that ensure data quality.

For many products, including many pharmaceuticals and foods, particle size is a performance defining characteristic. During granulation, for example, control of particle size may be vital, to ensure the production of granules that meet the requirements of subsequent processing steps and/or deliver the required performance in a finished product. Inline PSD measurement enables robust process monitoring and control. In the pharmaceutical industry these capabilities support the application of QbD, scoping of the Design Space and the development of continuous manufacturing in line with recent FDA guidance.

The Parsum IPP-80 inline probe provides continuous particle size and size distribution data, via the technique of spatial filter velocimetry. Measuring in the range of 50µm to 6000µm the probe is able to robustly analyse powders as well as pellets and large granules. It has been fully optimised to meet the rigours of the process environment and has no moving parts or user-accessible components. Extremely stable optics mean that the probe is resistant to the effects of vibration and requires no manual alignment. The software includes a range of diagnostic features for measurement verification and self-diagnosis to ensure trouble-free operation and safeguard data quality. The Parsum IPP-80 has been specified for use in an environment where hygiene is a priority and has a sanitary stainless steel design that is easy to clean with any conventional cleaning agent. It is ATEX certified for Zone 0/20 operation.

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